The role of epidermal growth factor receptor as progression factor in cervical intraepithelial neoplasia and squamous cell carcinoma

Background: Cervical carcinoma is the most common cancer with a prevalence of 28.6% all cancers in women Indonesia and one leading causes death among gynecologic malignancies. Prevention understanding are needed terms initiation development precancerous lesions into cervical cancer. About 90% squamous cell carcinomas that develop from intraepithelial neoplasia. Epidermal Growth Factor Receptor (EGFR) an expression product proto-oncogene c-erbB-1 (HER-1), which plays role proliferation, differentiation acceleration transformation malignant cells. This study aimed to prove EGFR as progression factor neoplasia carcinoma.Methods: The design was cross-sectional analytic observational study, total sample 36, taken biopsy or surgery patients (CIN) invasive (SCC), whose tissues were examined at Anatomical Pathology Laboratory, Faculty Medicine, Universitas Udayana/Sanglah General Hospital. Histopathological diagnosis determination type malignancy carried out by staining Hematoxylin Eosin (H & E). immunohistochemical stain evaluated expression.Results: age range CIN 21-48 years SSC 33-61 years, mean 41.8 ± 10.55 years. A 16 (44.4%) showed namely 9 (25%) low-grade CIN, 7 (19.4%) high-grade 20 (55.6%) SCC. There significant difference SCC (p = 0.004). between 0.035) 0.003). no 0.441). Conclusion: has SCC, probably because this situ also included CIN.